The series revolves around two brothers : Lincoln Burows who is sentenced to death for a crime he didn’t commit, and Michael Scoffield, a genius, who devises an elaborate plan to help him escape from the prison.
He held up a bank with the aim of going to the same prison as his brother. Before going there he is tattooed all the stages of his plan on his body.
His plan that he thought perfect does not unroll like he wants and he has to change it a lot of times to reach his aim.
Indeed, some prisoners that he counted on to go out of the prison will not cooperate necessarily and others who will discover his plans will want to come with them ; but at the end of Season 1, after many events, they manage to escape : Michael, his brother and all the other prisoners who helped him escape.
But the adventure is not finished and in Season 2 they will have to hide from the police of the country in particular the FBI agent who follows them to be able to reach Panama.
In Season 3, Michael and his brother manage to reach Panama but even there evrything doesn’t go as they had planned.
Those who committed the crime for which Lincoln was accused manage to send Michael into a prison in Panama but it contains no rules, prisoners make the laws themselves.
Lincoln will have to save him in his turn.